glutathione s-transferase p neurodegeneration transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Oxytosis/Ferroptosis in Neurodegeneration: the Underlying

2011 Mar 1 [cited

6 (10), eaaz0575

They also identified a significant delay in wound healing in GPx-4 knockout corneal epithelial cells and that the addition of -tocopherol significantly improved the delay in wound healing caused by GPx-4 knockout ( Corneal Endothelial Cell Dysfunction Corneal endothelial cells (CEnCs) are a layer of a single hexagonal-shaped cells adherent to the Descemets membrane in the innermost cornea layer ( Retinal Pigment Epithelial-Associated Eye Diseases Age-related macular degeneration (AMD), as an irreversible neurodegenerative disorder of the macular tissue, is accompanied by progressive vision loss, which gravely affects quality of life and is the main cause of blindness in elderly people in developed countries ( via the end-products of lipid peroxidation ( GSH is the most potent antioxidant in RPE cells, with high levels in the retina and RPE cells ( in vitro model of AMD to prove that GSH reduced the RPE death induced by ferroptosis and autophagy and observed that ferroptosis inhibitors inhibited primary RPE cell death more effectively than apoptosis or necrosis inhibitors

Davidson J, Shen Z, Gong X, Pollack JR

10.1111/adb.12667 Addict Biol